This Troper had a Forgotten Realms campaign where Beholders were helping Githyanki clear out Underdark Illithid settlements (as well as whoever else struck the Beholder's fancy) with the remnants of a long dead war god. They functioned much as fantasy nukes.

Locate City. You know the rest.

A forum role-play this troper was involved with was heavily based off of {{Okami}} ... eventually, someone got the idea that channeling the direct essence of the setting's primary deity would literally be a thermonuclear weapon. This troper blames late-night AlienSwarm binges for something this ludicrous.